Description
A potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3nM; shows no affinity for other Bcl2 family members, including Bcl-XL, Mcl-1, or Bfl-1/A1; induces apoptotic cell death in a Bax-dependent manner, and induces calcium (Ca2+) release via inhibition of Bcl2/IP3R interaction; potently represses lung cancer in vivo, and induces Bcl2 conformational change in tumor tissues